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Mitochondria contain active DNA methyltransferase (mtDNMT1) as well as TET family demethylases (TET1, TET2), which regulate the balance between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) [15, 35]

Other routine blood and urine tests were generally non-contributory

inhalational made little difference in POCD at 3 months, but some data suggests that light depth of anesthesia (avoiding too deep anesthesia, as measured by BIS monitors) is associated with less POCD, possibly because overly deep anesthesia can cause more hypotension and hypoxia which injure mitochondria

Fat transfer is not always permanent in patients because some of the fat can atrophy or die over time

Glutathione acts as a shield, soaking up these unstable molecules before they can cause lasting issues