foxo4-dri mechanism of action regulates endothelial cell senescence via the P53 signaling pathway FOXO4-DRI induces keloid senescent fibroblast

Those interactions continue driving fibroblast activation, angiogenesis signaling, and metalloproteinase modulation long after the peptide has been metabolized and excreted

So when you add it to the semaglutide, you get increased efficacy with minimal worsening of side effects

For research reference only

Li Vivian SW, Ng Ser S, Boersema Paul J, Low Teck Y, Karthaus Wouter R, Gerlach Jan P, Mohammed S, Heck Albert JR, Maurice Madelon M, Mahmoudi T, Clevers H (2012) Wnt signaling through inhibition of -catenin degradation in an intact axin1 complex

Circadian Rhythm Research The peptide has been investigated for its potential interactions with circadian signaling and pineal-associated molecular pathways