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Yan MS, Marsden PA

Loss-of-function variants in DAMP sensors such as TLR4 (Asp299Gly), purinergic receptor P2X, and ligand-gated ion channel 7 (P2RX7) (Glu496Ala) are associated with poor responses to anthracyclines and platinum-based chemotherapy due to impaired innate immune activation following DAMP release