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For example, it has been suggested that creatine helps to stabilize cellular membranes (Persky 2001)

Freezer storage at minus 20 degrees Celsius extends shelf life to multiple years but requires preventing moisture condensation when opening frozen vials

Family history can be ambiguous or absent because of the following reasons: inadequate family history information in medical charts, misdiagnosis of ALS in older generations, reluctance to report hereditary disease, loss of contact between family members, low penetrance, small family size, early death due to other causes, development of ALS in offspring before the parent who transmitted the defective gene exhibits symptoms themselves, genetic pleiotropy, and lack of information on biological parents (i.e., adoption and illegitimacy) [122]

Immune reconstitution inflammatory syndrome and the central nervous system