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Yes, vitamin B12 deficiency can contribute to depression

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(I later filed a grievance against ALL doctors involved and they were sanctioned, but fat lot of good that did me!) That I was diagnosedeven as I was so weak and neurologically compromised that I could hardly walkwas because, WHILE TOO WEAK TO GET OFF THE SOFA, I was watching a PBS program exploring Mary Todd Lincolns pernicious anemia and when they listed the symptoms, I screamed to my husband, Those are my symptoms! We SPECIFICALLY DEMANDED tests, the next day, (by a reluctant doctor) for intrinsic-factor antibodies, although by that time, my B-12 levels were through the basement

Interestingly, vitamin B12 is the largest known biomolecule and the only nutrient that has a stable carbon-metal bond