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Mechanically, tumor tissues tend to enhance their own antioxidant defenses in response to high levels of oxidative stress by up-regulating SLC7A11 expression, while SLC7A11-mediated synthesis of GSH acts as a defense against the cytotoxic effects of radiotherapy or certain drugs, which further reduces the sensitivity of tumor cells to treatment

The approximately 4,000-gene figure is the headline quantitative claim and originates from Pickart & Margolina's 2018 work

64.0y, p 2.67: 15.0% vs

Similarly, those on anticoagulants should discuss glutathione safety given potential vitamin K interactions with certain formulations

These alterations often correlate with clinical severity [137]