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Currently, the clinical evidence supporting a relationship between VitB12 and insomnia are very limited and mixed, with both positive and negative findings

This led some authors to propose a chaperone competition model, in which aggregates, client, and metastable proteins (polyQ, huntingtin, ATXN1, and superoxide dismutase-1) rival for finite chaperone resources [64]

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Fragoulis GE, Evangelatos G, Arida A et al (2020) Treatment adherence of patients with systemic rheumatic diseases in COVID-19 pandemic