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3.3 Co-culture systems Co-culture models in the lung are extensively employed to examine modifications in alveolar-capillary barrier function, mechanisms of viral or particulate infection (epithelial-macrophage culture), epithelial-mesenchymal associations to investigate remodeling of airway operations, and the influence of smooth muscle mast cell interactions on the reconstruction of the airway [42]

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MARCH was a 26-week, randomized, placebo-controlled (PBO), Phase 3 trial of maralixibat (MRX), an ileal bile acid transporter (IBAT) inhibitor, that achieved its primary and key secondary endpoints of pruritus and sBA reduction for individuals across the broadest range of PFIC types studied

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