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Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons

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Compared to either intervention alone, the study discovered that the combination therapy greatly enhanced insulin sensitivity and overall metabolic performance

Coupling reactions were performed with Fmoc-Xaa-OH in DMF (400 l, 0.4 M, 4.0 equiv.), HBTU in DMF (420 l, 0.38 M, 4.0 equiv.) and i Pr 2 NEt in NMP (200 l, 1.6 M, 8.0 equiv.) for 40 min, followed by washing with DMF (3 45 s)

Nonetheless, the precise molecular target of GHK-Cu has not been identified