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Cancer Research , 52 (22), 63716374

(2009), Muzykantov (2010), Carnemolla et al

Rashad SE, Haggran AA, Aboul-Elab EI, Shaalan AH, Abdoon ASS

The spectrum of cell types ranges from differentiated over undifferentiated adrenergic-to-mesenchymal cell types (triggered by adrenergic-to-mesenchymal transition), where malignant progression, therapy resistance and disease relapse are strongly associated with undifferentiated cell types

(3) Organ-centric reductionism: the current investigations predominantly focus on isolated organ systems, neglecting BBRs pleiotropic effects within inter-organ communication networks critical to systemic metabolic regulation