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Commonly reported side effects include headaches, localized irritation at the injection site, and transient changes in appetite

Status Scheduled requires update after meeting Evidence update log 17 July 2026 Initial evidence review published using regulator, anti-doping, trial-registry and peer-reviewed sources

Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers