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In healthy tissue, the CD47 cloak prevents phagocytic clearance, prolonging circulation, while in the diseased brain the CD47 is cleaved, exposing the NPs to microglial phagocytosis

GSSG generated by the oxidation of GSH is re-reduced to GSH under the catalysis of GSSG reductase (GSR), and NAD(P)H acts as a cofactor of GSR (Wu et al