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doi: 10.1371/journal.pone.0108849

De CarvalhoFALLorenzoJMPateiroMBermdezRPurriosLTrindadeMA

This is not without risk of side effects from the diuretic itself and diuretic side effects needs to be thoroughly reviewed with patients

We focused on inhibitors that disrupt the interaction between the calcium sensor Munc13-4 and the endosomal SNARE STX7

However, clinical translation faces significant challenges including off-target toxicity, limited efficacy, lack of predictive biomarkers, and emergence of adaptive resistance mechanisms