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This intracellular conversion has been confirmed pharmacokinetically: in a peer-reviewed human bioavailability crossover trial, SAG was undetectable in plasma following oral administration because rapid deacetylation occurs before or immediately upon systemic entry meaning the entire SAG load is converted to GSH before reaching blood circulation

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100107 min: 2535% B, 107108 min: 3595% B, 108118 min: 95% B