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28 The mechanisms by which diabetes promotes cardiomyopathy have received attention, especially due to abnormal cardiac metabolism (Cardiac Metabolism), glycotoxicity and lipotoxicity, and abnormal mitochondrial function causing oxidative stress and inflammation

The most frequent haplogroup in the study population was the Native American haplogroup A (34 patients, 12.23%), followed by the African haplogroup L1 (33 patients, 11.51%)

However, it exhibits low cell membrane permeability and demonstrates substantial toxicity in animal models, thereby constraining its potential application as a therapeutic agent (Zweygarth et al., 1986)

Mechanism based on peer-reviewed research

Combined impact of CHCHD10 p.Gly66Val and three other variants suggests oligogenic contributions to ALS