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doi: 10.1016/j.ijbiomac.2020.02.044 49 LiLWeiNMinZQLiYZhangXWuHyet al

Patients with the temporal lobe epilepsy-depression (TLE-D) phenotype are more prone to cognitive impairment, a finding that further supports the notion that TLE may affect both cognitive and emotional functions through multiple pathophysiological mechanisms (Bingaman et al., 2023)

However, for confirmed B12 deficiencyparticularly pernicious anaemia or neurological symptomsintramuscular hydroxocobalamin injections remain the first-line treatment in the UK, as recommended by NICE and the British Society for Haematology

Biochimica et Biophysica Acta (BBA) Reviews on Cancer 18(1) 188556 Ho E, Beaver LM, Williams DE, Dashwood RH

First, the specific pathogenic or protective microbial species, microbial-derived metabolites, and mimic antigens relevant to different NIU subtypes remain to be identified