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After reconstitution, use according to labspecific guidance and store as indicated on the product page

Incubation of the thiol product with a microsomal thiomethyltransferase and S -adenosylmethionine yielded the corresponding thiomethyl compound (Tateishi et al., 1978a)

This process involves many systems (intestines, kidneys, lungs, skin) but primarily takes place in the liver

For dogs - who have shorter digestive tracts than humans - this improved delivery mechanism is especially important for getting a meaningful therapeutic dose

The 48-week extension trial (TIPO-4) demonstrated sustained efficacy, with participants maintaining a total mean weight loss of 13-14kg over the extended treatment period, confirming long-term effectiveness without significant tolerance development