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Apart from receptor-mediated targeting, the enhanced permeability and retention (EPR) effect, or increased permeability and retention of nanoparticles, is also an efficient means by which nanoparticles localize in the tumour area because of the peculiarities of its vascularization and lack of efficient lymphatics [300]

Ovarian estrogens play a key role in the management of the reproductive system such as puberty, fertility, and estrous cycle mostly via interaction with nuclear estrogen receptors [7]

The duration of pain relief can also vary, with some experiencing long-lasting results and others requiring additional treatment

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When mitochondrial membrane is depolarized, hyperactive PARP1 binds to AIF, prompting its translocation from the mitochondrial to the nucleus [138]