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The B12 deficiency itself getting worse, either because not enough unhealthy red blood cells have expired and been replaced by healthy ones (each one of them has a 90 day life-cycle), or because the B12 wasnt injected on a daily schedule

Reviews flag this as an unresolved question, especially in patients with current or prior cancer (Sehgal et al., Pharmaceuticals, 2025)

Yet for the reasons we discussed above, researchers should carefully vet potential vendors for reputation, certifications, and consumer-friendly policies

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The timing of reward delivery proves crucial in determining these effects