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10.1126/science.1180962 114 KarasekM

doi: 10.17582/journal.jahp/2021/9.2.170.177 83

The downstream effects of the two enzymes are opposite: ACE activity leads to vasoconstriction, oxidative stress, inflammation and apoptosis, whereas ACE2 causes vasodilatation, angiogenesis and anti-inflammatory, anti-oxidative and anti-apoptotic effects [1]

Unlike many other antioxidants that you have to get from food, like Vitamin C or Vitamin E, your body actually produces its own glutathione

It is therefore possible that oxidant stress reduces remethylation and enhances transsulfuration to maintain, via an autocorrective process, the intracellular glutathione pool, which would be essential for the redox-regulating capacity of cells