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To a solution of methyl 3-iodo-1-isopropyl-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-6-carboxylate (30 mg, 0.086 mmol) and methyl 3-iodo-2-isopropyl-2,4,6,7-tetrahydropyrano[4,3-c]pyrazole-6-carboxylate (30.0 mg, 0.086 mmol) in dioxane (3 mL)/water (0.5 mL) was added Na 2 CO 3 (27.2 mg, 0.257 mmol), 2-(3-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (50.9 mg, 0.188 mmol) and PdCl 2 (dppf) (12.54 mg, 0.017 mmol) under N 2 atmosphere The mixture was stirred at 80 C

EULAR Abstract, Madrid (2017)

Osteoblast-osteoclast communication and Bone Homeostasis

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