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Vorinostat, as mentioned before, is a histone deacetylase inhibitor (HDACI) has limited efficacy against solid tumors because of r the development of resistant cells (Fantin and Richon, 2007)

By inhibiting NF-B activation, curcumin suppresses the transcription of pivotal pro-inflammatory mediators, including cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), COX-2, and iNOS

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Mice that received zinc were resistant to cyclophosphamide-induced reductions in numbers of white blood cells and mature T lymphocytes, suppression of IgM antibody production, and reduction of thymus weight (Zhang 1992)

(2023) 10:e2303053