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However, outcome from investigations using mice genetically manipulated for proteins integral or associated with the TJ have not been consistent and have resulted in diverse effects including immune adaptation and tolerance (summarized in Table 2)

doi: 10.3389/fcell.2022.1091580 Received 07 November 2022 Accepted 05 December 2022 Published 21 December 2022 Volume 10 - 2022 Edited by Jian Wang, Zhengzhou University, China Reviewed by Elena Polishchuk, Telethon Institute of Genetics and Medicine (TIGEM), Italy Li Zhang, Nanjing Brain Hospital Affiliated to Nanjing Medical University, China Anmu Xie, The Affiliated Hospital of Qingdao University, China Updates Copyright 2022 Li, Chen, Wang, Yao and Wang

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10.1093/ije/dyv080 6 BowdenJ.Davey SmithG.HaycockP