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Oxidative stress plays a critical role in the pathophysiology of obesity by increasing the inflammatory response in adipose tissue and stimulating the differentiation of preadipocytes into mature adipocytes, thereby inhibiting fatty acid oxidation (FAO) and ultimately promoting adipogenesis (Kasprzak-Drozd et al., 2022)

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The results showed that exposure to electronic cigarette extract (e-CSE) significantly increased superoxide generation in endothelial cells after exposure to e-CSE, and this effect was nicotine-concentration dependent, while the bioutilization of NO was significantly reduced