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When the antioxidant system cant withstand iron overload, excessive ROS will attack sensitive fatty acids, trigger peroxidation, destroy the integrity of cell membrane, increase oxidative stress in vivo , and destroy DNA, protein and lipids, thus aggravating lipid metabolism disorder and further causing ferroptosis (40)

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Further more, DNA isolated from sera and SF of different RA patients caused appreciable inhibition in the activity of anti-CE-modified DNA antibodies clearly showing the presence of oxidatively altered epitopes on the isolated DNA molecules, which could be directly correlated to estrogen/radical mediated oxidative stress [38]

Pills While glutathione pills are available, they lack the efficacy and long-lasting results of injections

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