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doi: 10.3389/fimmu.2022.845209 199 lvarez-RivasNSang-ParkHDaz del CampoPFernndez-CastroMCorominasHAndreuJLet al

It binds the KISS1R receptor with sub-nanomolar to low-nanomolar affinity in both rodent and human receptor models

American Family Physician, 96(6), 384-389

However, these side effects are often intermittent, mild, and short-lived, Fishman says

Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)