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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells

Setting up a precise mechanistic model of co-cultures will contribute to better controllability and stability in multi-species processes and enable upscaling and exploitation for biotechnological applications

Ascorbic acid supplementation does not attenuate post-exercise muscle soreness following muscle-damaging exercise but may delay the recovery process

GSH and GSSG concentration determination GSH and GSSG were quantified with a luminescence-based GSH/GSSG-Glo Assay per the manufacturers instructions (Promega, V6611)

It can spread more readily to distant sites in the body, like the lungs