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As Hippocrates said - "All disease begins in the gut"

Whereas histologic staging was formerly used as an independent predictor of the diseases natural history, the revised PSC survival model does not take into account the histologic stage (Kim et al, 2000)

It inhibits succinate dehydrogenase activity in the TCA cycle, activates the NRF2 pathway, and reduces IL-1 production, thereby exerting anti-inflammatory effects