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Description

The fatty acid omega hydroxylase genes (CYP4 family) in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD): An RNA sequence database analysis and review

Imaizumi T

Free Radic Biol Med 30: 11911212

Lipid metabolism disorders affect peroxidase expression levels, and the interaction between the two is such that peroxidase accumulates very long chain fatty acids (VLCFA), which are deposited on mitochondrial membranes affecting membrane fluidity, destabilizing the electron transport chain (ETC) complex, and leading to reduced ATP production and cell death