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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

Enhanced neuronal MET signalling levels in ALS mice delay disease onset

These types of models are commonly used to investigate how signaling molecules influence coordinated repair responses rather than isolated cellular processes

However, due to poor metabolic stability of angiotensin IV and many AnglV analogues, the inability of early analogues to penetrate the blood brain baixier, and the failure to identify the AT4 receptor, no pharmaceutical company has moved forward with their development