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doi: 10.1016/j.tox.2023.153506, 204

121 In the beginning, NADPH binds to the enzyme and reduces the flavin (eq 32), which in turn establishes a charge-transfer complex with one of the cysteines of the active site (Cys63), breaking the previous disulfide bond (eq 33)

A., Park J., Pei L., Baur J., Palmer M., Susztak K., Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis

[8] You are experiencing severe or continuous side effects (mentioned above) You continue to feel loss of interest in pleasurable activities or hobbies Your fatigue does not improve Your sleep is disturbed (insomnia, excessive sleeping) You continue to have difficulty concentrating You experience changes in appetite You experience physical aches and pains Because antidepressants alter your brain chemistry, discontinuing them without medical supervision can cause serious symptoms

2006 Jun;102(6):1638-45