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We performed non-targeted, accurate semiquantitative metabolomic analysis of human whole blood, plasma, and red blood cells during 3458 hr fasting of four volunteers

Statistical significance was determined by one-way ANOVA with post hoc Tukeys tests or two-way ANOVA as appropriate

[23] Activation of the PI3K pathway is currently associated with cell motility through remodeling of adhesion to the extracellular matrix as well as localized recruitment of transducers involved in cytoskeletal reorganization, such as RAC1 and PAK

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This process disrupts A-A interactions and leads to the depolymerization of preformed A fibrils into monomers (Figs