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Positive ANA titers were found in up to 70% of morphea patients, being associated with a higher risk for extracutaneous, deeper involvement and disease relapse (1, 2, 16, 26, 96, 100)

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Polyphenols and vitamin E can quench the triplet state of riboflavin through direct electronic energy transfer (Reference Huvaere, Olsen and Skibsted53) , while carotenoids scavenge-free radicals and ROS resulting from type I and type II photosensitisation (Reference Cardoso, Olsen and Skibsted54)

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Mangosteen is a seasonal fruit and bears most fruit during the heat of the summer between June and August / between November and February