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may marginally improve stability Avoid: Tap water, distilled water without sterilization, or solutions containing oxidizing agents Reconstitution Protocol Allow lyophilized vial to reach room temperature before opening Clean vial septum with alcohol swab Add diluent slowly along vial wall (not directly onto powder) Allow powder to dissolve without shaking

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Controversy surrounding the ANLS hypothesisis this the new paradigm

IM injections may require a longer needle and careful site placement but are still practical with proper guidance

Commonly implicated drugs that might precipitate or exacerbate RLS include antihistamines (particularly the sedating ones), selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs) and dopamine antagonists, such as metoclopramide