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Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells

5 A major cause of LBP is intervertebral disc degeneration (IDD): a chronic, progressive process associated with aging, 6 genetic predisposition, 7 smoking, 8 diabetes, 9 overweight, 10 and additional risk factors (ie, heavy physical labor or inactivity, atherosclerosis of spinal vessels, inflammatory diseases 11 )