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The result at week 68: Continued semaglutide 2.4 mg: lost an additional 7.9% of body weight (total loss from baseline: 17.4%) Switched to placebo: regained 6.9% of body weight (net loss from baseline: 5.0%) Thats a roughly 15-point difference in body weight between the two groups at the end of the trial, attributable entirely to whether the medication continued

However, because it is unknown why SCFA-mediated activation of another GPCR, Gpr41, lowers blood pressure, this SCFA feature remains poorly defined (Vallianou et al., 2020)