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(44) The CYP2E1 gene encodes a 56.9 KD enzyme that is capable of metabolizing drugs, hormones and xenobiotic toxins such as ethanol

In a pentylenetetrazole-induced convulsion model in mice, topiramate pretreatment decreased GSH levels and increased MDA levels, suggesting that TPM negatively regulates oxidative stress (Agarwal et al., 2011)

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Laffin says its best to steer clear of this supplement, as there isnt enough conclusive research

By contrast, diminished levels of delta wave activity are commonly seen in cases of brain injury, insomnia, narcolepsy, severe ADHD, and neurocognitive disorders [29, 30, 31, 32]