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201 Using a specific TP receptor antagonist and genetic editing of animals, Egan et al 202 revealed that COX-1 promoted early atherosclerosis and thrombosis by mediating TXA2 production and the downstream activation of the TP pathway

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doi: 10.1016/j.bbi.2015.07.004 236 DinarelloCA

Once reconstituted, store at 4C and follow the manufacturer's handling recommendations or your laboratory's validated procedures after reconstitution

Subsequently, it has been found to be useful in the treatment of hypercholesterolemia [1] with morbidity and potential mortality benefits [2]