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In preclinical models, GIP receptor agonism attenuates emesis while increasing the amount of body weight reduction in comparison to GLP- 1 agonism alone [148]

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It is obvious that no dissociation constants can be evaluated from plots of this kind, as the only standout feature in this plot is the buffer minimum around pH 7, whereas the (possible) occurrences of dissociation reactions around pH 3 and Figure 2