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First, mechanistic studies should combine single-cell spatial transcriptomics with mitochondrial metabolomics to map ferroptosis pathways in spinal ventral horn motor neurons, microglia, and astrocytes, with emphasis on the coupling between NCOA4-mediated ferritinophagy and SOD1/TDP-43 clearance, thereby establishing a dynamic model linking mitochondrial iron dysregulation, proteotoxic stress, and cell death

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The complex of LSM14 LSM and SeMet 4ET C V963M variant was concentrated to 12 mg ml 1 and crystallized at 4C using a reservoir solution containing 2 M (NH 4 ) 2 SO 4 , 2% PEG400, 0.1 M HEPES pH 7

Hyung-Joo Kang is an employee of CorEvitas, LLC

10.1039/tf9666200070 136 YagilG.AnbarM