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In physiological condition, DCs take up self- antigen and apoptotic cells and transport them to the lymph nodes [85]

The enzyme hydroxyacid-oxoacid transhydrogenase (HOT) (B) oxidizes gamma-hydroxybutyric acid, a potentially toxic metabolite, to succinic semialdehyde, simultaneously reducing 2-ketoglutaric acid to D-2-OH glutaric acid

observed that treatment with coenzyme Q10 (CoQ10) or lipoic acid upregulated ATP and SOD levels, while decreasing apolipoprotein E and A in AD models

The same logic applies to the mid-face and jawline