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However, in conditions like ischemic stroke and spinal cord injury, CHAC1 promotes neuronal damage by inducing ferroptosis through the depletion of GSH, a critical antioxidant, exacerbating oxidative stress and worsening the injury (Mei et al., 2017

10.3390/ijms20010039 19 ChuB.KonN.ChenD.LiT.LiuT.JiangL.et al (2019)

Bridge models to patients by aligning human-proximal systemsorganoids, microphysiological chips and point-of-care (POC) modalitieswith lab-grade validation (chromatography/spectrometry, calibrated reporters) to ensure external validity

However, in this field, various areas remain in which high-quality evidence is lacking, despite their clinical significance

Cancer Med (2017) 6:168697