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PDE5I medications enhance this process by preventing the breakdown of cyclic guanosine monophosphate (cGMP), a molecule that promotes smooth muscle relaxation and blood vessel dilation

The metabolic enzyme methionine adenosyltransferase 2 alpha (MAT2A) is a key regulator of cellular metabolism and is primarily responsible for catalyzing the conversion of L-methionine and adenosine triphosphate (ATP) into S-adenosylmethionine (SAM) 8

Moses et al., 2014)

Finally, the method of narrative synthesis was utilized to organize and convey the findings effectively, adhering to the framework suggested by MacLure [20]

2014;125:s98 Pavlova E