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We previously showed that EBV-LMP1 not only upregulates DNMT1 expression and activity, but also promotes its mitochondrial translocation

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Specifically, BPDE can induce global hypomethylation by inhibiting DNA methyltransferases (DNMTs), which leads to the upregulation of oncogene expression and downregulation of tumor suppressor gene function, thus promoting the proliferation and metastasis of bladder cancer cells (Bukowska and Siciska, 2021