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As genetic variants are determined at conception they are much less affected by the confounders that can bias conventional observational studies, such as socioeconomic position, so MR studies minimize confounding

It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

The considerable TSB of SBS-PolkKO mutations suggests that the endogenous lesions driving mutation in the absence of Pol are also repaired by a transcription-coupled mechanism

GSTs bind and detoxify substrate in their dimeric form and therefore only protein dimers have been selected in this study

Daver N, Kantarjian H, Marcucci G, Pierce S, Brandt M, Dinardo C, Pemmaraju N, Garcia-Manero G, O'Brien S, Ferrajoli A, Verstovsek S, Popat U, Hosing C, Anderlini P, Borthakur G , Kadia T, Cortes J, Ravandi F