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Increasing evidence shows that NADPH is not only critical for regulating glutathione redox system, but also governs many other signaling, including ferroptosis 64,65 and disulfidptosis 66

Furthermore, the translocation to the plasma membrane of 78-kDa glucose-regulated protein GRP78, which facilitates M2 macrophage polarization of TAMs and tumor growth in lung cancer, was induced by IGF-1R signaling, and concomitant IGF-1 blockade and GRP78 knockdown in TAMs suppressed M2 macrophage-induced maintenance, proliferation, and migration of lung cancer cells (27)

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Nutrients 16 (21), 3705

doi: 10.1016/j.metop.2020.100066, 88