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doi: 10.1016/j.celrep.2017.07.055 42 TarangeloAMagtanongLBieging-RolettKTLiYYeJAttardiLDet al

The sedimentation-velocity experiments were performed using a double-sector epon charcoal-filled centerpiece at 20 C with a rotor speed of 42,000 rpm

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Because depleted glutathione impairs mitochondrial function and burdens the liver, the therapy is frequently paired with care for stubborn weight gain that has not responded to diet and exercise alone, supporting detoxification and metabolic efficiency rather than acting as a weight loss drug

Collectively, our results demonstrate a possible non-catalytic role of PTPN22 in modulating mTORC2 kinase activity in cells as well as in vitro