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Methylglyoxal (MG) is a highly reactive -oxoaldehyde that is primarily generated intracellularly through the spontaneous degradation of glycolytic triose phosphate intermediates, namely dihydroxyacetone phosphate and glyceraldehyde 3-phosphate

Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A

This direct transport method makes increases in intracellular glutathione levels happen more quickly and reliably

Conclusion : Inhibiting hepatic Wnt signaling results in lower levels of glutamine and mTOR activity, prompting an increase in autophagy that clears the accumulated porphyrin-protein complexes and helps alleviate porphyria (Figure 1)

R.ApplebaumS