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Pathogenic tau can seed synaptically connected cells and lead to the stimulation and aggregation of natively folded tau in naive cells, leading to further progression of the disease ( A laboratory study conducted on transgenic mice expressing human non-mutant tau was used to assess the impact of the post-translational hyper-phosphorylation of tau on the central and peripheral nervous system after a period of 3 and 6 months ( PET imaging studies on Alzheimers disease have shown that cognition has a better correlation with tau pathology than with A-plaque deposition (Shaw et al., 2009

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Clinical Relevance As mentioned, the significance of its particular skin wound therapy was not especially reviewed

Zhang, L.J

10.1038/cdd.2015.117 Cell Death Differentiation 106 ShiY.-L.WeilandM.LiJ.HamzaviI.HendersonM.HugginsR