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revealed that putting sparfloxacin in PLGA-NPs improves ocular penetration and prolongs the precorneal resident time, enhancing its therapeutic efficacy [113]

@sralphlim

The abstract of the published study indicates that it works, but the results tell a different story

doi: 10.1371/journal.pone.0020456 33 ZmoraNSuezJElinavE

This is in contrast to conventional maleimide reagents, which hydrolyze to form unreactive maleamic amides 35 or undergo side reactions with amine groups 31,32,36,37